Under the supervision of a senior scientific staff member, perform synthesis and characterization of small molecules to support internal and collaborative drug discovery and development efforts
Multi-step synthesis (7-12 steps) of new molecules and analogues of lead candidates (milligram to gram scale) individually or in a library format
Multi-step synthesis (3-5 steps) of fragments and building blocks to be incorporated into molecules (gram to kilogram scale)
Purification (flash chromatography, HPLC, crystallization, distillation) and analytical characterization (NMR, IR, LC-MS) of aforementioned molecules and fragments
Design of syntheses for construction of target molecules
Development of route optimization schemes to permit larger scale synthesis of molecules and fragments
Assist in the development of new synthetic processes and improvement of existing procedures to support advanced compound development.
Synthetic procedure preparation, presentation of results internally and externally
Planning work and completion of tasks on schedule
Maintain up-to-date records for all work performed and ensure a safe workplace
